Reviewing the genetic alterations in high-risk cutaneous squamous cell carcinoma: A search for prognostic markers and therapeutic targets.

doi:10.1002/hed.24765

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Article

Reviewing the genetic alterations in high-risk cutaneous squamous cell carcinoma: A search for prognostic markers and therapeutic targets.

Head & neck - 1 Jul 2017

Ashford Bruce G, Clark Jonathan, Gupta Ruta, Iyer N Gopalakrishna, Yu Bing, Ranson Marie

Abstract excerpt

Cutaneous squamous cell carcinoma (SCC) is second only in incidence to basal cell carcinoma (BCC), effecting up to 500 000 people in the United States annually. Metastasis to regional lymph nodes occurs in approximately 5% of cases and imparts significant morbidity. Standard treatment in this group involves a combination of surgery and adjuvant radiation. Currently, there are no clinically useful biomarkers of...

Read the complete abstract on PubMed

Topics

Biomarkers, Tumor
Carcinoma, Squamous Cell
Female
Genetic Predisposition to Disease
Genetic Variation
Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Lymphatic Metastasis

Male

Molecular Targeted Therapy

Mutation

Neoplasm Metastasis

Prognosis

Skin Neoplasms

Source

Open in PubMed

Identifiers

PMID: 28370784
DOI: 10.1002/hed.24765

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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