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Article

Genomic analysis of metastatic cutaneous squamous cell carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2015

Li Yvonne Y, Hanna Glenn J, Laga Alvaro C, Haddad Robert I, Lorch Jochen H, Hammerman Peter S

Abstract excerpt

PURPOSE: A rare 5% of cutaneous squamous cell carcinomas (cSCC) metastasize, lack FDA-approved therapies, and carry a poor prognosis. Our aim was to identify recurrent genomic alterations in this little-studied population of metastatic cSCCs. EXPERIMENTAL DESIGN: We performed targeted sequencing of 504 cancer-associated genes on lymph node metastases in 29 patients with cSCC and identified mutations and somatic...

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Source

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Identifiers

PMID: 25589618
DOI: 10.1158/1078-0432.CCR-14-1773
PMCID: PMC4359951

Genes

BRAF
EGFR
FGFR3
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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