Article

Chromatin rewiring mediates programmed evolvability via aneuploidy

2018-09-03

Abstract excerpt

Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis 1 , and yet specific aneuploidies can be adaptive during environmental stress 2,3 . Here, we identify a chromatin-based system for inducible aneuploidy in a human pathogen. Candida albicans utilizes chromosome missegregation to acquire resistance to antifungal drugs 4,5 and for ploidy...

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Literature Corpus work: 2d69c1ac-001f-522e-ab06-5e72494aab93
DOI: 10.1101/407841

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