Article
Aneuploidy Causes Non-genetic Individuality.
Cell - 6 Apr 2017
Beach Rebecca R, Ricci-Tam Chiara, Brennan Christopher M, Moomau Christine A, Hsu Pei-Hsin, Hua Bo, Silberman Rebecca E, Springer Michael, Amon Angelika
Abstract excerpt
Phenotypic variability is a hallmark of diseases involving chromosome gains and losses, such as Down syndrome and cancer. Allelic variances have been thought to be the sole cause of this heterogeneity. Here, we systematically examine the consequences of gaining and losing single or multiple chromosomes to show that the aneuploid state causes non-genetic phenotypic variability. Yeast cell populations harboring the...
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