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Article

Mitotic Recombination and Adaptive Genomic Changes in Human Pathogenic Fungi

7 Nov 2019

Abstract excerpt

Genome rearrangements and ploidy alterations are important for adaptive change in the pathogenic fungal species Candida and Cryptococcus, which propagate primarily through clonal, asexual reproduction. These changes can occur during mitotic growth and lead to enhanced virulence, drug resistance, and persistence in chronic infections. Examples of microevolution during the course of infection were described in both...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 31703352
DOI: 10.3390/genes10110901

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