Article

Evaluation of a six-minute walk test in the DE50-MD canine model of Duchenne muscular dystrophy and its effect on blood-borne biomarkers

2025-03-17

Abstract excerpt

<h4>Background: </h4> Duchenne muscular dystrophy (DMD) is a fatal muscle wasting disease caused by mutations in the dystrophin gene resulting in cycles of muscle degeneration, inflammation and regeneration. The 6-minute walk test (6MWT) is a key functional outcome measure for DMD patient clinical trials and has been adapted for use in animal models of the disease. The DE50-MD dog model of DMD closely reflects the...

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Literature Corpus work: 2d424a58-3cd2-53e7-8dfd-b1266934396c
DOI: 10.12688/wellcomeopenres.23269.2

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