Article

Long-term, age-associated activity quantification in the DE50-MD dog model of Duchenne muscular dystrophy (DMD)

2025-03-29

Abstract excerpt

<h4>ABSTRACT</h4> Animal models with a clinically relevant phenotype remain important for robust evaluation of novel therapeutics for the fatal, X-linked genetic disorder, Duchenne Muscular Dystrophy (DMD). Demonstration of functional improvement is crucial for both patients and regulatory authorities. DMD is associated with a decline in musculoskeletal function with progressive paresis, muscle atrophy and fibros...

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Literature Corpus work: efb7abd5-6c30-5ddc-b5c2-3b0b5f03f795
DOI: 10.1101/2025.03.26.645481

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