Article

Longitudinal assessment of blood-borne musculoskeletal disease biomarkers in the DE50-MD dog model of Duchenne muscular dystrophy

2022-08-17

Abstract excerpt

<h4>Background: </h4> Duchenne muscular dystrophy (DMD) is a fatal muscle wasting disease caused by mutations in the dystrophin gene. Due to their phenotypic similarity to human patients, large animal models are invaluable tools for pre-clinical trials. The DE50-MD dog is a relatively new model of DMD, and carries a therapeutically-tractable mutation lying within the hotspot for human patients, making it especiall...

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Literature Corpus work: a5cfaf75-55d2-5f9d-b846-5146f113dc4b
DOI: 10.12688/wellcomeopenres.17398.2

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