Article

Functional Shotgun Metagenomic Insights into Gut Microbial Pathway and Enzyme Disruptions Linking Metabolism, Affect, Cognition, and Suicidal Ideation in Major Depressive Disorder

2025-12-12

Abstract excerpt

<h4>Background</h4> Major depression (MDD) is linked to neuro-immune, metabolic, and oxidative stress (NIMETOX) pathways. The gut microbiome may contribute to these pathways via leaky gut and immune-metabolic processes. <h4>Aims</h4> To identify gut microbial alterations in MDD and to quantify functional pathways and enzyme gene families and integrate these with the clinical phenome and immune–metabolic biomarke...

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Literature Corpus work: 162e3d69-7ad8-5666-82a7-77804bf055b6
DOI: 10.64898/2025.12.10.25342027

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