Article

A Shift Toward Proteolytic Gut Fermentation Links Systemic Inflammation to Clinical Phenotypes in Major Depressive Disorder

2026-03-24

Abstract excerpt

<h4>Background</h4> The "Neuro-Immune-Metabolic-Oxidative Stress" (NIMETOX) theory identified systemic dysregulation in Major Depressive Disorder (MDD), yet the precise gut-derived metabolic triggers initiating this cascade remain elusive. This study investigated the interplay between fecal short-chain fatty acids (SCFAs), systemic immune activation, and clinical phenotypes to identify a potential "gut-immune bio...

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Literature Corpus work: 366dcc25-bff3-5a19-b1b7-b1da0d9b13b0
DOI: 10.64898/2026.03.22.26348995

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