A shift toward proteolytic gut fermentation links systemic inflammation to clinical phenotypes in major depressive disorder.

doi:10.1016/j.pnpbp.2026.111900

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Article

A shift toward proteolytic gut fermentation links systemic inflammation to clinical phenotypes in major depressive disorder.

Progress in neuro-psychopharmacology & biological psychiatry - 30 Aug 2026

Niu Mengqi, Luo Yiping, Yangyang Chenkai, Almulla Abbas F, Carvalho Andre F, Li Jing, Zhang Yingqian, Maes Michael

Abstract excerpt

BACKGROUND: The "Neuro-Immune-Metabolic-Oxidative Stress" (NIMETOX) theory identified systemic dysregulation in Major Depressive Disorder (MDD), yet the precise gut-derived metabolic triggers initiating this cascade remain elusive. This study investigated the interplay between fecal short-chain fatty acids (SCFAs), systemic immune activation, and clinical phenotypes to identify a potential "gut-immune biotype"...

Read the complete abstract on PubMed

Topics

Humans
Major Depressive Disorder
Male
Female
Fatty Acids, Volatile
Inflammation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Phenotype

Feces

Gastrointestinal Microbiome

Middle Aged

Fermentation

Biomarkers

Source

Open in PubMed

Identifiers

PMID: 42636957
DOI: 10.1016/j.pnpbp.2026.111900

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