Article

Facilitating Gene Editing in Human Lymphoma Cells Using Murine Ecotropic γ-Retroviruses

2024-12-03

Abstract excerpt

Genetic modifications using CRISPR-Cas9 have revolutionized cancer research and other pre-clinical studies. Exceptionally, these efficient tools are inadequate in a few disease models and cell lines due to the aberrant differentiation states and the accumulation of excessive somatic mutations that compromise the robustness of viral gene delivery and stable transduction. A couple of B lymphoma cell lines fall into...

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Literature Corpus work: 2d006238-2c3c-5626-9efe-95ea216d9b82
DOI: 10.1101/2024.12.03.626526

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