Article

Multiple Alu exonizations in 3’UTR of a primate specific isoform of CYP20A1 creates a potential miRNA sponge

2020-06-09

Abstract excerpt

<title>Abstract</title> <p>Background: Alu repeats contribute to phylogenetic novelties in conserved regulatory networks in primates. Exaptation of Alus in transcript isoforms could nucleate large-scale mRNA-miRNA interactions and modulate cellular outcomes. <h4>Result:</h4> Using a functional genomics approach, we report a transcript isoform of an orphan gene, CYP20A1 (CYP20A1_Alu-LT) that arise through exonizat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fc502d94-efaa-5a75-84cb-c39fbc195d4c
DOI: 10.21203/rs.3.rs-33372/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multiple Alu exonizations in 3’UTR of a primate specific isoform of CYP20A1 creates a potential miRNA spongeDOI 10.21203/rs.3.rs-33372/v1Read

Multiple Alu exonizations in 3’UTR of a primate specific isoform of CYP20A1 creates a potential miRNA spongeSemantic proximity Read

Origin of a novel <i>CYP20A1</i> transcript isoform through multiple Alu exaptations creates a potential miRNA spongeSemantic proximity Read

Exonized Alu repeats in the 3’UTR of a CYP20A1_Alu-LT transcript act as a miRNA spongeSemantic proximity Read

The RNA Atlas, a single nucleotide resolution map of the human transcriptomeSemantic proximity Read

A single mutation in ACTR8 gene results in lineage-specific expression in primatesSemantic proximity Read

Structurally conserved primate lncRNAs are transiently expressed during human cortical differentiation and influence cell type specific genesSemantic proximity Read

Genome-wide RNA structure changes during human neurogenesis drive gene regulatory networksSemantic proximity Read

Retro-miRs: Novel and functional miRNAs originated from mRNA retrotranspositionSemantic proximity Read

A compendium of conserved cleavage and polyadenylation events in mammalian genes.Semantic proximity Read

Warning SINEs: <i>Alu</i> elements, evolution of the human brain, and the spectrum of neurological diseaseSemantic proximity Read

Retro-miRs: Novel and functional miRNAs originating from mRNA retrotranspositionSemantic proximity Read

The Functional Map of Ultraconserved Regions in Humans, Mice and RatsSemantic proximity Read