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Article

Evolutionary dynamics of cancer in response to targeted combination therapy.

eLife - 25 Jun 2013

Bozic Ivana, Reiter Johannes G, Allen Benjamin, Antal Tibor, Chatterjee Krishnendu, Shah Preya, Moon Yo Sup, Yaqubie Amin, Kelly Nicole, Le Dung T, Lipson Evan J, Chapman Paul B, Diaz Luis A, Vogelstein Bert, Nowak Martin A

Abstract excerpt

In solid tumors, targeted treatments can lead to dramatic regressions, but responses are often short-lived because resistant cancer cells arise. The major strategy proposed for overcoming resistance is combination therapy. We present a mathematical model describing the evolutionary dynamics of le...

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Identifiers

PMID: 23805382
DOI: 10.7554/eLife.00747
PMCID: PMC3691570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-23805382-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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