Validation of polymorphic Gompertzian model of cancer through <i>in vitro</i> and <i>in vivo</i> data

Abstract excerpt

Mathematical modeling plays an important role in our understanding and targeting therapy resistance mechanisms in cancer. The polymorphic Gompertzian model, analyzed theoretically by Viossat and Noble, describes a heterogeneous cancer population consisting of therapy sensitive and resistant cells. This theoretically promising model has not previously been validated with real-world data. In this study, we provide t...

Topics

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• Algorithms
• Carcinoma, Non-Small-Cell Lung
• Computer Simulation
• Drug Resistance, Neoplasm
• Evolution, Molecular
• Genotype
• Models, Genetic
• Phenotype

Identifiers and source

Literature Corpus work

febcc918-ee87-5b2e-bfd5-0888ec2450d6

DOI

10.1101/2023.04.19.537467