Article

Nemo-like kinase regulates Progranulin levels in the brain through the microglial endocytosis-lysosomal pathway

2018-06-28

Abstract excerpt

Genetic variants in Granulin (GRN) , which encodes the secreted glycoprotein Progranulin (PGRN), are associated with several neurodegenerative diseases including frontotemporal lobar degeneration, neuronal ceroid lipofuscinosis, and Alzheimer’s disease. These genetic alterations manifest in pathological changes due to a reduction of PGRN expression; therefore, identifying a factor that can modulate PGRN levels i...

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Literature Corpus work: 2cd3c5f9-9ab3-59a7-b03a-fa7999fed3a0
DOI: 10.1101/358010

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