Article

DECODER: A probabilistic approach to integrate big data reveals mitochondrial Complex I as a potential therapeutic target for Alzheimer’s disease

2018-04-17

Abstract excerpt

Identifying gene expression markers for Alzheimer’s disease (AD) neuropathology through meta-analysis is a complex undertaking because available data are often from different studies and/or brain regions involving study-specific confounders and/or region-specific biological processes. Here we introduce a novel probabilistic model-based framework, DECODER, leveraging these discrepancies to identify robust biomarker...

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Literature Corpus work: 2ccdb22f-ecee-5164-9d07-35797f384f53
DOI: 10.1101/302737

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