Article

Standard treatment against paediatric BRAF-V600E glioma promotes senescence and sensitizes tumours to BCL-xL inhibition

2026-01-14

Abstract excerpt

<h4>Background</h4> Chemo-, radio-, and targeted therapies can induce senescence in tumour cells, a process called therapy-induced senescence (TIS), which can be exploited therapeutically using compounds that kill senescent cells (senolytics). Children with BRAF-V600E activated brain tumours are commonly treated with Dabrafenib, Trametinib or Vinblastine (alone or in combination) with good responses. However, a s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2cc41b4c-b697-5d4b-8b1c-80b5e4a0c036
DOI: 10.64898/2026.01.13.698644

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Standard treatment against paediatric BRAF-V600E glioma promotes senescence and sensitizes tumours to BCL-xL inhibitionDOI 10.64898/2026.01.13.698644Read

Targeted inhibition of Bcl-xL following radiation reduces tumourigenesis in preclinical models of H3K27M-altered diffuse midline gliomaSemantic proximity Read

Navitoclax acts synergistically with irradiation to induce apoptosis in preclinical models of H3K27M-altered diffuse midline glioma.Semantic proximity Read

BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytomaSemantic proximity Read

Dual Targeting of MAPK Signaling and Senescence-Associated Survival Pathways Overcomes Vincristine Resistance in Fusion-Negative RhabdomyosarcomaSemantic proximity Read

Targeting Bcl-xL with Navitoclax Effectively Eliminates Senescent Tumor Cells That Appear Following CEP-1347-Induced Differentiation of Glioma Stem CellsSemantic proximity Read

Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL InhibitionSemantic proximity Read

Metronomic topotecan impedes tumor growth ofMYCN-amplified neuroblastoma cellsin vitroandin vivoby therapy induced senescenceSemantic proximity Read

Survival advantage combining a BRAF inhibitor and radiation in BRAF V600E-mutant glioma.Semantic proximity Read

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic AstrocytomaSemantic proximity Read

Radiation-Induced Cellular Senescence Reduces Susceptibility of Glioblastoma Cells to Oncolytic Vaccinia VirusSemantic proximity Read

Phase II Weekly Vinblastine for Chemotherapy-Naïve Children With Progressive Low-Grade Glioma: A Canadian Pediatric Brain Tumor Consortium Study.Semantic proximity Read

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngiomaSemantic proximity Read