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BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytoma

17 Aug 2022

Abstract excerpt

BACKGROUND: Pilocytic astrocytoma (PA) is the most common pediatric brain tumor and a mitogen-activated protein kinase (MAPK)-driven disease. Oncogenic MAPK-signaling drives the majority of cells into oncogene-induced senescence (OIS). While OIS induces resistance to antiproliferative therapies, it represents a potential vulnerability exploitable by senolytic agents. METHODS: We established new patient-derived PA...

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Share to Glioma Diagnosis and Treatment
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PMID: 35977048
DOI: 10.1093/neuonc/noac199

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