Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting Bcl-xL with Navitoclax Effectively Eliminates Senescent Tumor Cells That Appear Following CEP-1347-Induced Differentiation of Glioma Stem Cells

20 Jul 2025

Abstract excerpt

Cellular senescence is a state of the durable cell cycle arrest of dysfunctional cells, which has been associated with the promotion of tumor cell reprogramming into a stem cell state. We previously reported that the mixed lineage kinase (MLK) inhibitor CEP-1347 promotes the differentiation of glioma stem cells (GSCs)—key contributors to glioblastoma recurrence and therapy resistance—into non-stem tumor cells....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glioma Diagnosis and Treatment
Share to Nanoplatforms for cancer theranostics
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40725230
DOI: 10.3390/ijms26146984

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting Bcl-xL with Navitoclax Effectively Eliminates Senescent Tumor Cells That Appear Following CEP-1347-Induced Differentiation of Glioma Stem CellsPMID 40725230Read ↗

Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL InhibitionSemantic proximity Read ↗

BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytomaSemantic proximity Read ↗

Mitochondrial damage triggers therapy-induced senescenceSemantic proximity Read ↗

How to train glioma cells to die: molecular challenges in cell deathSemantic proximity Read ↗

Senolytic-Mediated Elimination of Head and Neck Tumor Cells Induced Into Senescence by Cisplatin.Semantic proximity Read ↗

Palbociclib Effectively Halts Proliferation but Fails to Induce Senescence in Patient-Derived Glioma Stem CellsSemantic proximity Read ↗

P21 Overexpression Promotes Cell Death and Induces Senescence in Human GlioblastomaSemantic proximity Read ↗

Senescence in neural cell lines: comparative insights from SH-SY5Y and ReNcell VMSemantic proximity Read ↗

Glioblastoma Multiforme Stem Cell Cycle Arrest by Alkylaminophenol through the Modulation of EGFR and CSC Signaling PathwaysSemantic proximity Read ↗

Navitoclax acts synergistically with irradiation to induce apoptosis in preclinical models of H3K27M-altered diffuse midline glioma.Semantic proximity Read ↗

P21 Overexpression Promotes Cell Death and Induces Senescence in Human GlioblastomaSemantic proximity Read ↗

The Bcl-2 inhibitor Obatoclax overcomes resistance to histone deacetylase inhibitors SAHA and LBH589 as radiosensitizers in patient-derived glioblastoma stem-like cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.