Article
Survival advantage combining a BRAF inhibitor and radiation in BRAF V600E-mutant glioma.
Journal of neuro-oncology - 1 Feb 2016
Dasgupta Tina, Olow Aleksandra K, Yang Xiaodong, Hashizume Rintaro, Nicolaides Theodore P, Tom Maxwell, Aoki Yasuyuki, Berger Mitchel S, Weiss William A, Stalpers Lukas J A, Prados Michael, James C David, Mueller Sabine, Haas-Kogan Daphne A
Abstract excerpt
Radiation (RT) is critical to the treatment of high-grade gliomas (HGGs) but cures remain elusive. The BRAF mutation V600E is critical to the pathogenesis of 10-20% of pediatric gliomas, and a small proportion of adult HGGs. Here we aim to determine whether PLX4720, a specific BRAF V600E inhibitor, enhances the activity of RT in human HGGs in vitro and in vivo. Patient-derived HGG lines harboring wild-type BRAF...
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