Navitoclax acts synergistically with irradiation to induce apoptosis in preclinical models of H3K27M-altered diffuse midline glioma.

doi:10.1038/s41598-025-32676-6

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Article

Navitoclax acts synergistically with irradiation to induce apoptosis in preclinical models of H3K27M-altered diffuse midline glioma.

Scientific reports - 22 Dec 2025

Vardon Ashley, Haston Scott, Hamdi Hiba, Cooksley Grace, Guiho Romain, Carvalho Diana, Carter Rebecca, Boult Jessica Katherine Rowena, Gharai Daniel, Cloete Ielyaas, Grey James, Apps John, Zhou Daohong, Zheng Guangrong, Martínez-Máñez Ramón, Lythgoe Mark Francis, Donovan Laura Kate, Carcaboso Angel Montero, Williams Owen, Hong Ying, Alexandre Paula, Gil Jesus, Dean Jamie Adam, Michod David, Jones Chris, Hargrave Darren, Martinez-Barbera Juan-Pedro

Abstract excerpt

Diffuse midline gliomas (DMGs) with histone H3K27M mutations represent a devastating paediatric brain cancer characterised by abysmal prognosis and limited treatment options. The only approved treatment is radiotherapy (RT), but most of the tumours relapse with fatal consequences. The effects of RT remain unknown because patients are not biopsied during treatment. Here, we sought to investigate whether...

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PMID: 41430412
DOI: 10.1038/s41598-025-32676-6
PMCID: PMC12749289

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