Article

Dual Targeting of MAPK Signaling and Senescence-Associated Survival Pathways Overcomes Vincristine Resistance in Fusion-Negative Rhabdomyosarcoma

2025-08-01

Abstract excerpt

<h4>ABSTRACT</h4> Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma, with limited therapeutic options for relapsed or metastatic disease. Fusion-negative (FN) RMS, the predominant subtype, frequently harbors mutations activating the RAS/MAPK pathway, yet the mechanisms underlying chemoresistance remain poorly defined. Here, we generated vincristine-resistant FN RMS cell lines through long-te...

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Literature Corpus work: 00db2ceb-5f6b-55ae-9e8c-b0030bc429ce
DOI: 10.1101/2025.07.29.667542

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