Article

Targeted inhibition of Bcl-xL following radiation reduces tumourigenesis in preclinical models of H3K27M-altered diffuse midline glioma

2024-12-20

Abstract excerpt

<h4>Background</h4> Diffuse midline gliomas (DMGs) with histone H3K27M mutations represent a devastating paediatric brain cancer characterized by abysmal prognosis and limited treatment options. The only approved treatment is radiotherapy (RT), but most of the tumours relapse with fatal consequences. In this study, we sought to investigate whether irradiation leads to senescence induction and explore the efficacy...

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Literature Corpus work: 3f291cc3-df15-5918-9452-669315fc5bad
DOI: 10.1101/2024.12.20.629607

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