Article

Cell-of-Origin, not Oncogenic Effect, Determines Desmoplastic Immune Exclusion in KRAS-Driven Liver Cancer

2026-03-26

Abstract excerpt

Intrahepatic cholangiocarcinoma (iCCA) and hepatocellular carcinoma (HCC) are the two most common primary liver cancers and share common risk factors. Yet they exhibit distinct oncogenic driver landscapes and fundamentally different tumor microenvironments (TME), with iCCA characterised by dense desmoplastic stroma that limits therapeutic efficacy. Whether these differences reflect oncogenic context or the develop...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2cb5c7bf-6059-553c-9f75-732e4489297d
DOI: 10.64898/2026.03.24.711280

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell-of-Origin, not Oncogenic Effect, Determines Desmoplastic Immune Exclusion in KRAS-Driven Liver CancerDOI 10.64898/2026.03.24.711280Read

Novel microenvironment-based classification of intrahepatic cholangiocarcinoma with therapeutic implicationsSemantic proximity Read

Molecular pathogenesis of intrahepatic cholangiocarcinomaSemantic proximity Read

Deciphering cholangiocarcinoma heterogeneity and specific progenitor cell niche of extrahepatic cholangiocarcinoma at single-cell resolutionSemantic proximity Read

Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinomaSemantic proximity Read

Heterogeneity of Cholangiocarcinoma Immune BiologySemantic proximity Read

The Immune–Genomics of Cholangiocarcinoma: A Biological Footprint to Develop Novel ImmunotherapiesSemantic proximity Read

Single‐Cell and Spatial Transcriptomics Delineate the Microstructure and Immune Landscape of Intrahepatic Cholangiocarcinoma in the Leading‐Edge AreaSemantic proximity Read

Single-cell analysis defines LGALS1+ fibroblasts that promote proliferation and migration of intrahepatic cholangiocarcinomaSemantic proximity Read

Heterogeneity, crosstalk, and targeting of cancer-associated fibroblasts in cholangiocarcinomaSemantic proximity Read

Targeting protein hyper-SUMOylation halts cholangiocarcinoma progression by impairing cancer cell viability and tumor-stroma cross talkSemantic proximity Read

Tumour architecture shapes polarized epithelial states that predict survival in high-grade serous ovarian cancerSemantic proximity Read

An oncogenic phenoscape of colonic stem cell polarizationSemantic proximity Read