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Article

Targeting protein hyper-SUMOylation halts cholangiocarcinoma progression by impairing cancer cell viability and tumor-stroma cross talk

11 Feb 2025

Abstract excerpt

BACKGROUND AND AIMS: Cholangiocarcinoma (CCA) includes a diverse group of biliary malignancies with poor prognosis. Alterations in post-translational modifications contribute to disrupted protein dynamics, cellular disturbances, and disease. This study investigates the role of protein SUMOylation in cholangiocarcinogenesis and its potential as a therapeutic target. APPROACH AND RESULTS: Analysis of CCA tumors...

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PMID: 39932259
DOI: 10.1097/hep.0000000000001259

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