Article

ncBAF, a chromatin remodeler, enhances PXR-mediated transcriptional activation in the human and mouse liver

2023-02-04

Abstract excerpt

Pregnane X receptor (PXR) is one of the key regulators of drug metabolism, gluconeogenesis, and lipid synthesis in the human liver. Activation of PXR by drugs such as rifampicin, simvastatin, and efavirenz causes adverse reactions such as drug□drug interaction, hyperglycemia, and dyslipidemia. The inhibition of PXR activation has merit in preventing such adverse events. Here, we demonstrated that bromodomain conta...

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Literature Corpus work: 2ca9ba1f-5f8e-527b-9e1d-7e71769e46f4
DOI: 10.1101/2023.02.03.527063

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