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Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer

20 Jul 2021

Abstract excerpt

Epigenetic deregulation plays an essential role in hepatocellular carcinoma (HCC) progression. Bromodomains are epigenetic "readers" of histone acetylation. Recently, bromodomain inhibitors have exhibited promising therapeutic potential for cancer treatment. Using transcriptome sequencing, we identified BRPF1 (bromodomain and PHD finger containing 1) as the most significantly upregulated gene among the 43...

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PMID: 34285329
DOI: 10.1038/s42003-021-02405-6

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