Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterizing the role of the dark kinome in neurodegenerative disease – A mini review

20 Sept 2021

Abstract excerpt

BACKGROUND: Drugs that modulate previously unexplored targets could potentially slow or halt the progression of neurodegenerative diseases. Several candidate proteins lie within the dark kinome, those human kinases that have not been well characterized. Much of the kinome (~80%) remains poorly studied, and these targets likely harbor untapped biological potential. SCOPE OF REVIEW: This review highlights the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Melanoma and MAPK Pathways
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34547390
DOI: 10.1016/j.bbagen.2021.130014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterizing the role of the dark kinome in neurodegenerative disease – A mini reviewPMID 34547390Read ↗

Defining the Neural Kinome: Strategies and Opportunities for Small Molecule Drug Discovery to Target Neurodegenerative DiseasesSemantic proximity Read ↗

Clinically Precedented Protein Kinases: Rationale for Their Use in Neurodegenerative DiseaseSemantic proximity Read ↗

Protein Kinases and Neurodegenerative DiseasesSemantic proximity Read ↗

Polypharmacology is an enduring and nearly universal property of kinase inhibitorsSemantic proximity Read ↗

Protein Kinases and Parkinson’s DiseaseSemantic proximity Read ↗

Genetic mutations in kinases: a comprehensive review on marketed inhibitors and unexplored targets in Parkinson's diseaseSemantic proximity Read ↗

Targeting dementias through cancer kinases inhibitionSemantic proximity Read ↗

The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implicationsSemantic proximity Read ↗

Alterations in protein kinase networks in astrocytes and neurons derived from patients with familial Alzheimer’s DiseaseSemantic proximity Read ↗

DYRK1A kinase inhibition with emphasis on neurodegeneration: A comprehensive evolution story-cum-perspectiveSemantic proximity Read ↗

Leucine Rich Repeat Kinase 2: beyond Parkinson's and beyond kinase inhibitors.Semantic proximity Read ↗

Identification of Kinase inhibitors as PINK1 activators for the treatment of Parkinson’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.