Article

Defining the Neural Kinome: Strategies and Opportunities for Small Molecule Drug Discovery to Target Neurodegenerative Diseases

2020-04-02

Abstract excerpt

<h4>ABSTRACT</h4> Kinases are highly tractable drug targets that have reached unparalleled success in fields such as cancer but whose potential has not yet been realized in neuroscience. There are currently 55 approved small molecule kinase-targeting drugs, 48 of which have an anti-cancer indication. The intrinsic complexity linked to central nervous system (CNS) drug development and a lack of validated targets h...

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Literature Corpus work: 1ff454fa-c09d-597f-b50a-99464c60fa75
DOI: 10.1101/2020.04.01.020206

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