Article

5-hydroxymethylcytosine deposition mediates Polycomb Repressive Complex 2 function in <i>MYCN</i> -amplified neuroblastoma

2025-07-09

Abstract excerpt

<h4>ABSTRACT</h4> MYCN -amplification is a strong predictor of poor prognosis in neuroblastoma, an embryonal malignancy that accounts for 15% of pediatric cancer deaths. Here, we found that MYCN -amplified neuroblastoma tumors had increased 5-hydroxymethylcytosine (5-hmC) deposition on Polycomb Repressive Complex 2 (PRC2) target genes. 5-hmC and H3K27me3, a catalytic product of PRC2, directly co-localized at the...

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Literature Corpus work: 78fd3f1b-998c-5b71-a261-6504040712a7
DOI: 10.1101/2025.07.05.663256

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