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Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice

29 Apr 2024

Abstract excerpt

More than 1200 genes have been shown in the database to be expressed predominantly in the mouse testes. Advances in genome editing technologies such as the CRISPR/Cas9 system have made it possible to create genetically engineered mice more rapidly and efficiently than with conventional methods, which can be utilized to screen genes essential for male fertility by knocking out testis-enriched genes. Finding such...

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PMID: 38697008
DOI: 10.1016/j.jri.2024.104252

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