Article

Genetic background and transient prenatal disruption of vitamin A signaling determine susceptibility to airway hyperresponsiveness in mice

2025-11-03

Abstract excerpt

Airway structural changes and hyperresponsiveness (AHR), hallmarks of asthma, are crucially influenced by genetic variations and adverse exposures. While intrauterine environmental perturbations leading to dysfunctional lung development have been linked to adult pulmonary disease, still little is known about the developmental events leading to these postnatal abnormalities. Here, we provide evidence of genetic bac...

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Literature Corpus work: 2c62d420-ee69-5a09-8535-4c615c5aa2ec
DOI: 10.1101/2025.10.31.685835

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