Article
Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice.
The Journal of clinical investigation - 1 Feb 2014
Chen Felicia, Marquez Hector, Kim Youn-Kyung, Qian Jun, Shao Fengzhi, Fine Alan, Cruikshank William W, Quadro Loredana, Cardoso Wellington V
Abstract excerpt
There is increasing evidence that vitamin A deficiency in utero correlates with abnormal airway smooth muscle (SM) function in postnatal life. The bioactive vitamin A metabolite retinoic acid (RA) is essential for formation of the lung primordium; however, little is known about the impact of early fetal RA deficiency on postnatal lung structure and function. Here, we provide evidence that during murine lung...
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