Article
Genetic background influences developmental airway smooth muscle program and susceptibility to airway hyperresponsiveness in mice.
JCI insight - 8 Sept 2026
Otoshi Takehiro, Kotton Benjamin D, Kameshwar Ayyappa Ks, Seki Yoshinori, Cardell Zachary, Ke Xiangyi, Matsuno Yuta, Rajaram Pooja, Kim Youn-Kyung, Sharpton Sarah M, Quadro Loredana, Cardoso Wellington V, Suzuki Masako
Abstract excerpt
Airway structural remodeling and hyperresponsiveness (AHR), hallmarks of asthma, are influenced by genetic variations and adverse exposures. While intrauterine perturbations in lung development have been linked to adult pulmonary disease, the developmental origins of these abnormalities remain poorly understood. Here, we provide evidence of genetic background playing a key role in this process. Using A/J and...
Read the complete abstract on PubMedTopics
- Animals
- Mice
- Muscle, Smooth
- Female
- Mice, Inbred C57BL
- Transforming Growth Factor beta