Article

Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply in <i>KRAS</i> mutant colorectal cancer

2023-05-05

Abstract excerpt

The nutrient status of the tumor microenvironment has major impacts on cell growth. Under nutrient depletion, asparagine synthetase (ASNS)-mediated asparagine production increases to sustain cell survival. G protein-coupled estrogen receptor-1 (GPER1) signaling converges via cAMP/PI3K/AKT with KRAS signaling to regulate ASNS expression. However, the role of GPER1 in CRC progression is still debated, and the effec...

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Literature Corpus work: 2c4eeac9-0072-5bd1-b7a9-ce810b7161f0
DOI: 10.1101/2023.05.05.539577

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