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Article

Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancer.

International journal of cancer - 1 Jan 2025

Lu Lingeng, Zhang Qian, Aladelokun Oladimeji, Berardi Domenica, Shen Xinyi, Marin Audrey, Garcia-Milian Rolando, Roper Jatin, Khan Sajid A, Johnson Caroline H

Abstract excerpt

Survival differences exist in colorectal cancer (CRC) patients by sex and disease stage. However, the potential molecular mechanism(s) are not well understood. Here we show that asparagine synthetase (ASNS) and G protein-coupled estrogen receptor-1 (GPER1) are critical sensors of nutrient depletion and linked to poorer outcomes for females with CRC. Using a 3D spheroid model of isogenic SW48 KRAS wild-type (WT)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Glutamine

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Share to Proto-Oncogene Proteins p21(ras)

Share to Receptors, Estrogen

Share to Receptors, G-Protein-Coupled

Source

Open in PubMed Open full text

Identifiers

PMID: 39039782
DOI: 10.1002/ijc.35104
PMCID: PMC11537827

Genes

KRAS
ASNS
GPER1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancer.PMID 39039782Read ↗

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