Article
Resurrecting the Alternative Splicing Landscape of Archaic Hominins using Machine Learning
2022-08-04
Abstract excerpt
Alternative splicing contributes to adaptation and divergence in many species. However, it has not been possible to directly compare splicing between modern and archaic hominins. Here, we unmask the recent evolution of this previously unobservable regulatory mechanism by applying SpliceAI, a machine-learning algorithm that identifies splice altering variants (SAVs), to high-coverage genomes from three Neanderthals...
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Identifiers and source
- Literature Corpus work
- 2c3caf39-dae7-5b25-9096-05ccedaece84
- DOI
- 10.1101/2022.08.02.502533