Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping the gene regulatory landscape of archaic hominin introgression in modern Papuans.

PLoS genetics - 1 Mar 2026

Comerford Maddy, Vespasiani Davide M, Shukla Navya, Cook Laura E, Yermakovich Danat, Dannemann Michael, Leavesley Matthew, Kinipi Christopher, Ricaut François-Xavier, Brucato Nicolas, Cox Murray P, Gallego Romero Irene

Abstract excerpt

Interbreeding between anatomically modern humans and archaic hominins has contributed to the genomes of present-day human populations. However, our understanding of the specific gene regulatory consequences of Neanderthal, and particularly, Denisovan introgression is limited. Here, we used a massively parallel reporter assay to investigate the regulatory effects of 25,869 high-confidence introgressed SNPs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Gene Frequency

Share to Genetic Introgression

Share to Hominidae

Share to Neanderthals

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 41875405
DOI: 10.1371/journal.pgen.1012067
PMCID: PMC13012733

Genes

IFIH1
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping the gene regulatory landscape of archaic hominin introgression in modern Papuans.PMID 41875405Read ↗

Mapping the gene regulatory landscape of archaic hominin introgression in modern PapuansSemantic proximity Read ↗

Denisovan introgression has shaped the immune system of present-day PapuansSemantic proximity Read ↗

Large-scale functional screen identifies genetic variants with splicing effects in modern and archaic humans.Semantic proximity Read ↗

Large scale functional screen identifies genetic variants with splicing effects in modern and archaic humansSemantic proximity Read ↗

Detection of Neanderthal Adaptively Introgressed Genetic Variants That Modulate Reporter Gene Expression in Human Immune Cells.Semantic proximity Read ↗

A global map for introgressed structural variation and selection in humansSemantic proximity Read ↗

Immune context unmasks regulatory effects of Neanderthal and Denisovan introgressionSemantic proximity Read ↗

Impact and evolutionary determinants of Neanderthal introgression on transcriptional and post-transcriptional regulationSemantic proximity Read ↗

Neanderthal introgression reintroduced functional ancestral alleles lost in Eurasian populations.Semantic proximity Read ↗

Genetic architecture of gene regulation in Indonesian populations identifies QTLs associated with local ancestry and archaic introgressionSemantic proximity Read ↗

Neanderthal introgression reintroduced functional alleles lost in the human out of Africa bottleneckSemantic proximity Read ↗

Long-range regulatory effects of Neandertal DNA in modern humansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.