Article

Evaluating the effects of archaic protein-altering variants in living human adults

2024-07-06

Abstract excerpt

Advances in paleo-genetics allowed the identification of protein-coding changes arising on the lineage leading to Homo sapiens , by comparing genomes of present-day and archaic hominins. Experimental validation of the potential impact of such changes has so far been restricted to functional assays and model organisms. Large-scale biobanking now makes it possible to identify present-day carriers of archaic alleles...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2746e7ba-91e4-5f76-81a4-3b26948fdfe1
DOI: 10.1101/2024.07.05.602242

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evaluating the effects of archaic protein-altering variants in living human adultsDOI 10.1101/2024.07.05.602242Read

Evaluating the effects of archaic protein-altering variants in living human adults.Semantic proximity Read

Exonic Variation and Its Clinical Impact in 7221 Old Order Amish.Semantic proximity Read

Temporal mapping of derived high-frequency gene variants supports the mosaic nature of the evolution of Homo sapiens.Semantic proximity Read

Deciphering the role of structural variation in human evolution: a functional perspective.Semantic proximity Read

Population Structure, Stratification, and Introgression of Human Structural Variation.Semantic proximity Read

Resurrecting the Alternative Splicing Landscape of Archaic Hominins using Machine LearningSemantic proximity Read

Human stem cell resources are an inroad to Neandertal DNA functionsSemantic proximity Read

A catalog of single nucleotide changes distinguishing modern humans from archaic homininsSemantic proximity Read

Partitioning the genomic journey to becoming <i>Homo sapiens</i>Semantic proximity Read

Human Stem Cell Resources Are an Inroad to Neandertal DNA Functions.Semantic proximity Read

Population Structure, Stratification and Introgression of Human Structural VariationSemantic proximity Read

Predicting Archaic Hominin Phenotypes from Genomic Data.Semantic proximity Read