Article

Biases in arginine codon usage correlate with genetic disease risk

2019-10-31

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> The persistence of hypermutable ‘CGN’ (CGG, CGA, CGC, CGU) arginine codons at high frequency suggests the possibility of negative selective pressure at these sites and that arginine codon usage could be a predictive indicator of human disease genes. <h4>Methods</h4> We analyzed arginine codons (CGN, AGG, AGA) from all ‘canonical’ Ensembl protein coding gene transcripts before...

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Literature Corpus work: 2c28b7a4-a3fa-56cf-935b-7386962833a8
DOI: 10.1101/825703

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