Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolutionary constrained genes associated with autism spectrum disorder across 2,054 nonhuman primate genomes.

Molecular autism - 23 Jan 2025

Kikuchi Yukiko, Uddin Mohammed, Veltman Joris A, Wells Sara, Morris Christopher, Woodbury-Smith Marc

Abstract excerpt

BACKGROUND: Significant progress has been made in elucidating the genetic underpinnings of Autism Spectrum Disorder (ASD). However, there are still significant gaps in our understanding of the link between genomics, neurobiology and clinical phenotype in scientific discovery. New models are therefore needed to address these gaps. Rhesus macaques (Macaca mulatta) have been extensively used for preclinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autism Spectrum Disorder
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NRXN1 gene

Share to Genetic Predisposition to Disease

Share to Genome

Share to Macaca mulatta

Share to Phenotype

Share to Primates

Source

Open in PubMed Open full text

Identifiers

PMID: 39849619
DOI: 10.1186/s13229-024-00633-1
PMCID: PMC11755938

Genes

AUTS2
CACNA1D
MBD5
NRXN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolutionary constrained genes associated with autism spectrum disorder across 2,054 nonhuman primate genomes.PMID 39849619Read ↗

Evolutionary constraint genes implicated in autism spectrum disorder across 2,054 nonhuman primate genomesSemantic proximity Read ↗

Comorbid Analysis of Genes Associated with Autism Spectrum Disorders Reveals Differential Evolutionary ConstraintsSemantic proximity Read ↗

Genetic diversity of 1,845 rhesus macaques improves genetic variation interpretation and identifies disease models.Semantic proximity Read ↗

Whole genome sequencing predicts novel human disease models in rhesus macaques.Semantic proximity Read ↗

The rhesus macaque is three times as diverse but more closely equivalent in damaging coding variation as compared to the human.Semantic proximity Read ↗

Genomic selection signatures in autism spectrum disorder identifies cognitive genomic tradeoff and its relevance in paradoxical phenotypes of deficits versus potentialities.Semantic proximity Read ↗

Analyses of Human Genetic Data to Identify Clinically Relevant Domains of Neuroligins.Semantic proximity Read ↗

Biases in arginine codon usage correlate with genetic disease riskSemantic proximity Read ↗

Phenotypic effects of genetic variants associated with autism.Semantic proximity Read ↗

Heritability of social behavioral phenotypes and preliminary associations with autism spectrum disorder risk genes in rhesus macaques: A whole exome sequencing study.Semantic proximity Read ↗

Forward and reverse genomic screens enhance the understanding of phenotypic variation in a large Chinese rhesus macaque cohortSemantic proximity Read ↗

Large-scale polymorphism discovery in macaque G-protein coupled receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.