Article

The genetic architecture of human programmed stop codon readthrough

2026-07-16

Abstract excerpt

Programmed translational readthrough produces C-terminally extended protein isoforms via decoding of stop codons by near-cognate tRNAs. Human genes experimentally validated as readthrough targets share a CUAG motif downstream of a UGA stop codon. However, the full sequence determinants of readthrough efficiency, how they combine, and how generalisable they are across genes remain largely unexplored. Here we use de...

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Literature Corpus work: 7f41d5ba-5b44-5d67-bd0b-0ecd13592097
DOI: 10.64898/2026.07.14.738498

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