Article

Targeting DNA repair pathways: mechanisms and potential applications in cancer therapy

2020-11-01

Abstract excerpt

DNA damage can be caused by both endogenous and environmental factors, such as replication errors, reactive oxygen species (ROS) and chemotherapeutic drugs. Accurate and effective repair of DNA damage can preserve the integrity of the genome. However, if left unrepaired or repaired inappropriately, DNA damage could lead to the development of a variety of diseases, including cancers. DNA damage response (DDR) pathw...

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Literature Corpus work: 2c1cdcf6-b2eb-5ee7-92a7-d352d9a690ba
DOI: 10.1007/s42764-020-00026-7

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