Article

DNA damage response inhibition‐based combination therapies in cancer treatment: Recent advances and future directions

2022-03-01

Abstract excerpt

Abstract DNA molecules are subject to various lesions that can be detrimental to the cells. DNA damage response (DDR) pathways encompass a variety of mechanisms that cells employ in response to DNA damage. While DDR promotes genomic stability in normal cells, it also protects cancer cells from DNA lesions, particularly against exogenous DNA‐damaging agents. Therefore, DDR pathways can be exploited to account for r...

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Literature Corpus work: 58365432-7e73-5d8e-a915-15722e8e6d38
DOI: 10.1002/aac2.12047

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