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Article

DNA Damage Repair Inhibitors-Combination Therapies.

Cancer journal (Sudbury, Mass.) - 1 Jan 2000

Smith Gabriella, Alholm Zachary, Coleman Robert L, Monk Bradley J

Abstract excerpt

ABSTRACT: DNA damage response and repair (DDR) is responsible for ensuring genomic integrity. It is composed of intricate, complex pathways that detect various DNA insults and then activate pathways to restore DNA fidelity. Mutations in this network are implicated in many malignancies but can also be exploited for cancer therapies. The advent of inhibitors of poly(ADP-ribose) polymerase has led to the...

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Identifiers

PMID: 34904813
DOI: 10.1097/PPO.0000000000000561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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