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DNA Damage Response in Cancer Therapy and Resistance: Challenges and Opportunities

24 Nov 2022

Abstract excerpt

Resistance to chemo- and radiotherapy is a common event among cancer patients and a reason why new cancer therapies and therapeutic strategies need to be in continuous investigation and development. DNA damage response (DDR) comprises several pathways that eliminate DNA damage to maintain genomic stability and integrity, but different types of cancers are associated with DDR machinery defects. Many improvements...

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PMID: 36499000
DOI: 10.3390/ijms232314672

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