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Article

Therapeutic Targeting of DNA Damage Response in Cancer

1 Feb 2022

Abstract excerpt

DNA damage response (DDR) is critical to ensure genome stability, and defects in this signaling pathway are highly associated with carcinogenesis and tumor progression. Nevertheless, this also provides therapeutic opportunities, as cells with defective DDR signaling are directed to rely on compensatory survival pathways, and these vulnerabilities have been exploited for anticancer treatments. Following the...

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PMID: 35163621
DOI: 10.3390/ijms23031701

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