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Targeting DNA repair for cancer treatment: Lessons from PARP inhibitor trials

1 Jan 2023

Abstract excerpt

Ionizing radiation is frequently used to treat solid tumors, as it causes DNA damage and kill cancer cells. However, damaged DNA is repaired involving poly-(ADP-ribose) polymerase-1 (PARP-1) causing resistance to radiation therapy. Thus, PARP-1 represents an important target in multiple cancer types, including prostate cancer. PARP is a nuclear enzyme essential for single-strand DNA breaks repair. Inhibiting...

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PMID: 37415740
DOI: 10.32604/or.2023.028310

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