Article

PTEN knockout using retrogradely transported AAVs restores locomotor abilities in both acute and chronic spinal cord injury

2023-04-17

Abstract excerpt

Restoring function in chronic stages of spinal cord injury (SCI) has often been met with failure or reduced efficacy when regenerative strategies are delayed past the acute or sub-acute stages of injury. Restoring function in the chronically injured spinal cord remains a critical challenge. We found that a single injection of retrogradely transported adeno-associated viruses (AAVrg) to knockout the phosphatase and...

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Literature Corpus work: 6e712fb3-7b7c-5850-b7e0-ba7fc727771a
DOI: 10.1101/2023.04.17.537179

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